Abstract #2276

The Effect of Physical Activity on 31P-MRS Bioenergetic Measurements and Assessment of Muscle Quality in the Baltimore Longitudinal Study of Aging

Ariel C. Zane¹, Donnie Cameron¹, Seongjin Choi¹, David A. Reiter², Kenneth W. Fishbein², Christopher M. Bergeron¹, Eleanor Simonsick¹, Richard G. Spencer², and Luigi Ferrucci³

¹Translational Gerontology Branch, NIH/National Institute on Aging, Baltimore, MD, United States, ²Laboratory of Clinical Investigation, NIH/National Institute on Aging, Baltimore, MD, United States, ³Intramural Research Program, NIH/National Institute on Aging, Baltimore, MD, United States

We examined the effect of high intensity physical activity on the post-exercise PCr recovery rate (k_PCr), testing whether the decline in muscle quality may be attributed to an age-related decline in muscle mitochondrial capacity. In-vivo ³¹P MRS measurements were obtained before, during, and after a rapid knee-extension exercise. The cross-sectional results in the BLSA show that both age and frequency of physical activity are significant predictors of k_PCr. However, neither is significantly correlated with a strength-based assessment of muscle quality.

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