Abstract #2284

Investigating Regional Variations of Acetyl Carnitine In Thigh and Calf Muscles In Vivo using PRESS Localized Long TE-based MR Spectroscopy

Rajakumar Nagarajan¹, Zohaib Iqbal¹, Manoj K Sarma¹, S. Sendhil Velan², and M.Albert Thomas¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore

Skeletal muscle plays a major role in the development of insulin resistance (IR) and progression to type 2 diabetes. A recent work has used long TE (350ms) based PRESS localized spectrum in the vastus lateralis region of thigh muscle without any exercise to investigate acetylcarnitine, a compound formed when acetyl-Coenzyme A exceeds use by the tricarboxylic cycle in the mitochondria. This work focused on examining regional variations of acetylcarnitine in the thigh and calf muscles using the long TE MRS. Our preliminary results show the unequivocal presence of acetylcarnitine in lean, young healthy thigh muscle regions and decreased level in one diabetic type 2 patient.

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