Abstract #2285

Quantitative Off-Resonance-Based Metallosis Assessment Near Total Hip Replacements: Correlating an Imaging Biomarker with Histology

Kevin M Koch¹, Matthew F Koff², Parina Shah², S S Kaushik¹, Andrew Nencka¹, and Hollis G Potter²

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ²Magnetic Resonance Imaging, Hospital for Special Surgery, New York, NY, United States

The failure of hip arthroplasty may be attributed to metallic or polyethylene debris generated from implant components. The metallic components, and their associated debris are composed of cobalt-chromium alloys, which have a strong paramagnetic magnetic susceptibility relative to biological materials. Previously, we demonstrated a mechanism to utilize MRI data to qualitatively highlight cobalt-chromium debris deposits in vivo. In the current study, we extend this work to provide a quantifiable regional metallosis metric. In addition, this regional quantitative metric is shown to statistically correlate with local histology metallosis scores in subjects undergoing total hip revision surgery.

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