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Abstract #2294

The changes in vertebra subchondral bone and cartilage endplate perfusion of degenerated intervertebral disks :a quantitative DCE-MRI study

Jiao WANG1, Yun fei ZHA1, Dong XING1, Lei HU1, Chang sheng LIU1, Hui LIN2, and Yuan LIN1

1Department of Radiology,Renmin Hospital of Wuhan University ,Wuhan 430060,China, Wu han, China, People's Republic of, 2GE Healthcare China, Shanghai 200000,China, Shang hai, China, People's Republic of

To explore the relationship between the vertebra subchondral bone (VSB), the cartilage endplate (CEP) perfusion with intervertebral disc degeneration (IVDD). 18 individuals underwent lumbar conventional and DCE-MRI. The cranial and caudal VSB and CEP perfusion parameters (Ktrans, Kep, Ve) were measured. The VSB perfusion parameters Kep of Pfirrmann I and II, Pfirrmann I and IV, Pfirrmann III and IV,the cranial CEP Kep of Pfirrmann III and II showed significant difference. In the early progress of IVDD, its metabolism increase compensatory, clinical research should put more emphasis on early onset stage of IVDD such as in Pfirrmann II.

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