Abstract #2295

Mitochondrial function as measured by 31P Magnetic Resonance Spectroscopy between lean Chinese and Asian-Indian males

Ivan P.W. Teng¹, Jamie X.M. Ho¹, Trina Kok¹, Philip Lee², Melvin K.S. Leow³, Hong Chang Tan⁴, Chin Meng Khoo⁵, George K Radda⁶, and Mary C Stephenson^1,5

¹Clinical Imaging Research Centre, A*STAR-NUS, Singapore, Singapore, ²SBIC, A*STAR, Singapore, Singapore, ³SICS, A*STAR, Singapore, Singapore, ⁴Department of Endocrinology, SGH, Singapore, Singapore, ⁵Department of Medicine, NUS, Singapore, Singapore, ⁶Biomedical Research Council, A*STAR, Singapore, Singapore

Previous studies have indicated differences in insulin sensitivity between lean Indian and Chinese men. In this study we used ³¹P MRS and a dorsiflexion task to assess muscle mitochondrial function, thought to be associated with insulin sensitivity, via PCr recovery rates. No inter-ethnic group differences were observed in measured blood parameters (HbA1c, fasting blood glucose level and M-value) between groups. However, positive correlations were observed between τPCr and both HbA1c and fasting blood glucose levels suggesting poorer mitochondrial function. No correlation was observed with M-value. Larger sampling sizes are necessary for these correlations and group differences to reach statistically-significant conclusions.

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