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Abstract #2295

Mitochondrial function as measured by 31P Magnetic Resonance Spectroscopy between lean Chinese and Asian-Indian males

Ivan P.W. Teng1, Jamie X.M. Ho1, Trina Kok1, Philip Lee2, Melvin K.S. Leow3, Hong Chang Tan4, Chin Meng Khoo5, George K Radda6, and Mary C Stephenson1,5

1Clinical Imaging Research Centre, A*STAR-NUS, Singapore, Singapore, 2SBIC, A*STAR, Singapore, Singapore, 3SICS, A*STAR, Singapore, Singapore, 4Department of Endocrinology, SGH, Singapore, Singapore, 5Department of Medicine, NUS, Singapore, Singapore, 6Biomedical Research Council, A*STAR, Singapore, Singapore

Previous studies have indicated differences in insulin sensitivity between lean Indian and Chinese men. In this study we used 31P MRS and a dorsiflexion task to assess muscle mitochondrial function, thought to be associated with insulin sensitivity, via PCr recovery rates. No inter-ethnic group differences were observed in measured blood parameters (HbA1c, fasting blood glucose level and M-value) between groups. However, positive correlations were observed between τPCr and both HbA1c and fasting blood glucose levels suggesting poorer mitochondrial function. No correlation was observed with M-value. Larger sampling sizes are necessary for these correlations and group differences to reach statistically-significant conclusions.

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