Abstract #2306

Development of facile protocols for stable nanoparticle formulations of 19F MR molecular imaging probes

Eric A Tanifum^1,2, Chandresh Patel¹, Robia Pautler², and Ananth Annapragada^1,2

¹Texas Children's Hospital, Houston, TX, United States, ²Baylor College of Medicine, Houston, TX, United States

Perfluorocarbons and perfluoropolyethers are currently the major molecules of choice in ¹⁹F MRI contrast agents. These molecules generally have magnetically diverse ¹⁹F atoms and are very hydrophobic. The later characteristic greatly hinders easy access to stable formulations for broad usage and the former generates chemical shift artifacts which result in blurred images. We have synthesized several hydrophilic organofluorine molecules all bearing magnetically equivalent ¹⁹F atoms and demonstrated that they are amenable to facile liposome nanoparticle formulation protocols. The resulting particles are highly stable and present a great potential for diverse applications as ¹⁹F MRI molecular imaging probes.

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