Abstract #2305

Nanocrystal Loaded Polymeric Microbubbles for Multimodal Imaging

Nutte Teraphongphom¹, Peter Chhour², John Eisenbrey³, Pratap Chandra Naha², Walter Witschey², Borirak Opasanont⁴, Lauren Jablonowski¹, David Peter Cormode², and Margaret Wheatley¹

¹Biomedical Engineering, Drexel University, Philadelphia, PA, United States, ²Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Radiology, Thomas Jefferson University, Philadelphia, PA, United States, ⁴Chemical and Biological Engineering, Drexel University, Philadelphia, PA, United States

To create multimodal contrast agents, we hypothesized that the shell of polymeric microbubbles could accommodate additional payloads. We therefore modified microbubbles by encapsulating nanoparticles including quantum dots, magnetic iron oxide nanoparticles, or gold nanoparticles to create bi-modality platforms in a manner that minimally compromised the performance for each individual imaging technique (ultrasound, fluorescence imaging, computed tomography and MRI).

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