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Abstract #2305

Nanocrystal Loaded Polymeric Microbubbles for Multimodal Imaging

Nutte Teraphongphom1, Peter Chhour2, John Eisenbrey3, Pratap Chandra Naha2, Walter Witschey2, Borirak Opasanont4, Lauren Jablonowski1, David Peter Cormode2, and Margaret Wheatley1

1Biomedical Engineering, Drexel University, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Radiology, Thomas Jefferson University, Philadelphia, PA, United States, 4Chemical and Biological Engineering, Drexel University, Philadelphia, PA, United States

To create multimodal contrast agents, we hypothesized that the shell of polymeric microbubbles could accommodate additional payloads. We therefore modified microbubbles by encapsulating nanoparticles including quantum dots, magnetic iron oxide nanoparticles, or gold nanoparticles to create bi-modality platforms in a manner that minimally compromised the performance for each individual imaging technique (ultrasound, fluorescence imaging, computed tomography and MRI).

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