Abstract #2308

A Targeted Host-Guest MRI Contrast Agent for Breast Cancer Molecular Imaging

Zhuxian Zhou^1,2, Zheng Han¹, and Zheng-Rong Lu¹

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Chemical and Biological Engineering, Zhejiang University, Hangzhou, China, People's Republic of

To produce MRI detectable signal enhancement for the biomarker on cancer cell surface, we developed a targeted host-guest nanosized contrast agent cRGD-POSS-βCD-(DOTA-Gd)-Cy5. The nanosized host-guest systems are preferable for facile synthesis of customized and functionalized imaging agent. Here, a cyclic peptide cRGD targeting to cancer cell α_vβ₃-integrin, a macrocyclic Gd(III) chelate and Cy5 fluorescent probes were loaded on the nanosized carrier by host-guest interaction. cRGD-POSS-βCD-(DOTA-Gd)-Cy5 can provide strong contrast enhancement to delineate malignant tumors during molecular MR and fluorescent imaging in a mouse 4T1 breast cancer model.

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