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Abstract #2309

Biodegradable glycoged-based nanoprobe as a multimodal tumor-targeting contrast agent

Andrea Galisova1, Daniel Jirak1, Marketa Jiratova1, Martin Hruby2, Maria Rabyk2, Aneta Pospisilova2, and Milan Hajek1

1MR Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Academy of Sciences, Institute of Macromolecular Chemistry, Prague, Czech Republic

An effective cancer diagnostic and therapeutic contrast agent with suitable properties including high specificity and safety is on high demand. In this study, accumulation of a biocompatible and biodegradable glycogen-based nanoprobe (GG-Gd-DOTA-Dy) was tested and compared to a commercially available contrast agent (gadoterate meglumine). Relaxivity and MR imaging of the probe was performed on the phantoms. The uptake of the agents was measured on the tumor-bearing rats at several time points after the contrast agent administration by MRI and fluorescence imaging. We found out that the novel probe is superior to a commercially available contrast agent regarding the relaxivity and accumulation in the tumor tissue.

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