Abstract #2317

Cell tracking with fluorine-19 MRI and zirconium-89 PET - a multi-modal approach

Kai D. Ludwig¹, Benjamin L. Cox^1,2,3, Myriam N. Bouchlaka^4,5, Stephen A. Graves¹, Justin J. Jeffery⁵, R. Jerry Nickles¹, Bryan P. Bednarz^1,6, Christian M. Capitini^4,5, and Sean B. Fain^1,6,7

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Morgridge Institute for Research, Madison, WI, United States, ³Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI, United States, ⁴Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States, ⁶Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁷Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Methods for non-invasive cell tracking may greatly enhance the ability to assess efficacy of cellular-based therapies. A dual-labeled (⁸⁹Zr and ¹⁹F) cell labeling approach could inform and potentially improve in vivo cell tracking sensitivity and clinical adoption. Here, we show longitudinal detection of localized cell injections with ¹⁹F MRI and the ability to quantify the number of cells within a voxel. Additionally, ⁸⁹Zr cell tracking results shows a high sensitivity for intravenous delivery of cells with longitudinal signal detection. Future work aims to combine both cell tracking approaches utilizing the dual-modality imaging platform on a PET/MRI system.

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