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Abstract #2318

Interaction of Manganese and Iron in R1 mapping in a Low Concentration Setting

Chien-Lin Yeh1, Carlos J. Perez-Torres1, and Ulrike Dydak1,2

1School of Health Sciences, Purdue University, West lafayette, IN, United States, 2Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Being able to use MRI to estimate brain Mn accumulation is of high interest in occupational Mn exposure settings. As a first step towards absolute quantification of brain Mn concentration in exposed humans using MRI, the interaction between Mn and Fe and their combined effect to R1 need to be explored. Our results suggest that a model only assuming independent linear contributions of Mn and Fe already explains the R1 data well. However introducing a cross term of Mn and Fe in the equation improves the fits, suggesting a Mn-Fe interaction.

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