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Abstract #2323

Quantifying exchange in host-guest systems for hyperpolarized xenon

Sergey Korchak1, Wolfgang Kilian1, Leif Schröder2, and Lorenz Mitschang1

1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany

The reversible binding of xenon to host structures is fundamental to the development of novel contrast agents employing hyperpolarized xenon and chemical exchange saturation transfer (HyperCEST) for molecular imaging. The rates for entering and leaving the host depend on atomic details and affect the obtainable contrast rendering them pivotal for the selection of hosts and optimization of imaging methods. However, different exchange processes may apply whose contributions are difficult to assign. Exchange spectroscopy experiments are proposed which enable straightforward disentanglement of the exchange kinetics and quantification of individual contributions. The approaches are exemplified for the cryptophane-xenon host-guest system.

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