Abstract #2324

CEST Nuclear Overhauser Enhancement imaging of protein misfolding in mice at different stages of prion disease

Eleni Demetriou¹, Mohamed Tachrount¹, Marilena Rega², Franscisco Torrealdea¹, Karin Shmueli³, Mark Farrow⁴, and Xavier Golay¹

¹Brain Repair and Rehabilitation, Institute of Neurology, London, United Kingdom, ²Institute of Neurology, London, United Kingdom, ³Medical Physics and Biomedical Engineering, University College of London, London, United Kingdom, ⁴MRC prion unit, Institute of Neurology, London, United Kingdom

Prion diseases are fatal neurodegenerative disorders which are caused by abnormal conformational changes of cellular prion protein. Chemical Exchange Saturation Transfer (CEST) imaging of NOE effects has been proposed as a new imaging mechanism to monitor protein folding by MRI. In this study, prion-infected mice were imaged at three stages of prion disease (asymptomatic, early-stage and late-stage) to investigate whether prion propagation could be detected in their brains. We concluded that NOE values at different stages of prion disease provide additional evidence of prion protein misfolding occurring in the brains of diseased mice.

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