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Abstract #2325

SUV-quantification in physiological lung tissue in an integrated PET/MR-System: Impact of lung density and bone tissue.

Ferdinand Seith1, Holger Schmidt1, Sergios Gatidis1, Ilja Bezrukov2, Christina Schraml1, Christina Pfannenberg1, Christian la Fougère3, Konstanin Nikolaou1, and Nina Schwenzer1

1Radiology, Universitätsklinikum Tübingen, Tübingen, Germany, 2Max-Planck-Institut, Tübingen, Germany, 3Nuclear Medicine, Universitätsklinikum Tübingen, Tübingen, Germany

Attenuation correction (AC) plays a key role in the quantification of tracer uptake in positron emission tomography (PET), expressed as standardized uptake value (SUV). The segmentation method is the standard approach for AC in whole-body PET/magnetic resonance imaging (MRI) that has been implemented into the software of most vendors. However, this method is neglecting bone and applies only one single patient-independent attenuation coefficient for the whole lung. Our study could demonstrate that both, differences lung density and surrounding bone tissue can have significant influence on SUV measurement of physiological lung tissue, mostly affecting the posterior regions.

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