Abstract #2326

IN VIVO 19F MRI QUANTIFICATION USING B1+/B1-CORRECTION

Ina Vernikouskaya^1,2, Alexander Pochert³, Mika Lindén³, and Volker Rasche^1,2

¹Internal Medicine II, University Hospital of Ulm, Ulm, Germany, ²Small Animal MRI, University of Ulm, Ulm, Germany, ³Inorganic Chemistry II, University of Ulm, Ulm, Germany

Quantification of ¹H MR contrast agents (CA) is limited by the only indirect visualization of the changes of the relaxation properties of the surrounding tissue. Using alternative nuclei such as fluorine (¹⁹F) as CA enables direct and quantifiable readout of local CA aggregations, since the ¹⁹F signal linearly correlates with its local concentration. However non-uniformity of the transmit/receive radiofrequency fields impact the resulting absolute signal, leading to wrong quantification results. Application of an easy-to-use time-efficient B₁⁺/B₁^--mapping technique for correction of the ¹⁹F signal in vivo is presented in this work.

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