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Abstract #2330

Direct arterial injection of hyperpolarized compounds into tumor tissue enables rapid detection of metabolism with minimal dilution

Steven Reynolds1, Stephen Metcalf2, Rebecca Collins3, Edward Cochrane3, Simon Jones3, Martyn Paley1, and Gillian Tozer2

1Academic unit of radiology, University of Sheffield, Sheffield, United Kingdom, 2Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom, 3Department of Chemistry, University of Sheffield, Sheffield, United Kingdom

Hyperpolarizing drug candidates could allow insights into their mode of action and metabolic fate. However, administering drug molecules at high concentrations can lead to adverse effects in animals. We have developed a method for directly administering substrates to tumor tissue by infusion through a single supplying artery, thus maximizing tumor drug delivery and minimizing T1 relaxation and systemic toxicity. The net signal gain for arterially injected 13C-pyruvate was x54, compared with the systemically administered venous route. Hyperpolarized custom 13C-labeled CA1 was arterially administered and its parent peak observed, in vivo, at its expected chemical shift (58ppm).

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