Abstract #2330

Direct arterial injection of hyperpolarized compounds into tumor tissue enables rapid detection of metabolism with minimal dilution

Steven Reynolds¹, Stephen Metcalf², Rebecca Collins³, Edward Cochrane³, Simon Jones³, Martyn Paley¹, and Gillian Tozer²

¹Academic unit of radiology, University of Sheffield, Sheffield, United Kingdom, ²Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom, ³Department of Chemistry, University of Sheffield, Sheffield, United Kingdom

Hyperpolarizing drug candidates could allow insights into their mode of action and metabolic fate. However, administering drug molecules at high concentrations can lead to adverse effects in animals. We have developed a method for directly administering substrates to tumor tissue by infusion through a single supplying artery, thus maximizing tumor drug delivery and minimizing T1 relaxation and systemic toxicity. The net signal gain for arterially injected ¹³C-pyruvate was x54, compared with the systemically administered venous route. Hyperpolarized custom ¹³C-labeled CA1 was arterially administered and its parent peak observed, in vivo, at its expected chemical shift (58ppm).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.