Abstract #2331

Characterisation of adipose tissue-derived mesenchymal stem cell using hyperpolarized MRS

Anja Bille Bohn¹, Nathalie Nielsen², Christoffer Laustsen², Hans Stødkilde-Jørgensen², and Lotte Bonde Bertelsen²

¹The department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark, ²MR Research Centre, Aarhus University, Aarhus University Hospital, Aarhus, Denmark

Synopsis: Studies of metabolism in stem cells have revealed a shift in the balance between glycolysis, mitochondrial oxidative phosphorylation and oxidative stress during the maturation of stem cells. In the stem cells, pyruvate from glycolysis will mainly be metabolized to lactate as a result of an uncoupling of the citric acid cycle and the oxidative phosphorylation pathway, thus the application of a novel metabolic cell culture tool could add valuable information to the studies of stem cell characterisation during development. In the present study we use hyperpolarised [1-13C] pyruvate to characterise mesenchymal stem cells harvested from adipose tissue.

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