Abstract #2334

Intraperitoneal substrate administration for ¹³C metabolic imaging in a mouse model of abdominal metastasis

Justin Y.C. Lau^1,2, Aws Abdul-Wahid³, Albert P. Chen⁴, Jean Gariépy^1,3, and Charles H. Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴GE Healthcare, Toronto, ON, Canada

Conventionally, hyperpolarized ¹³C substrates are administered via intravenous injection. In this abstract, a novel route of hyperpolarized substrate delivery via intraperitoneal injection is demonstrated for observing metabolism in a mouse model of abdominal metastasis. 2D CSI revealed lactate signal in tumour-bearing mice, but only pyruvate signal in a control mouse. An extended time window of dynamic metabolic imaging may be possible with intraperitoneal administration due to the longer in vivo pyruvate T₁ of 54 s as measured by dynamic 3D EPI. Intraperitoneal administration of hyperpolarized ¹³C substrates is a promising complementary technique well suited for observing poorly vascularized metastatic nodules.

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