Abstract #2335

In vivo Assessment of Metabolic Derangements in Renal Ischemia-Reperfusion Injury using Carbon-13 HP-MRI

Mehrdad Pourfathi^1,2, David D. Aufhauser³, Douglas R. Murken³, Zhonglin Wang³, Stephen J. Kadlecek¹, Heather Gatens¹, Ali Naji³, Matthew H. Levine^3,4, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Surgery, Division of Transplant Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States, ⁴Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Renal ischemia repercussion injury (IRI) and its manifestation of acute kidney injury (AKI) is a significant source of morbidity in diverse medical and surgical scenarios, for which for which there is no current therapeutic modality. AKI contributes significantly to hospital stay, morbidity, and mortality. Despite the extensive metabolic derangements that accompany renal IRI, there is an absence of clinically useful markers to predict the clinical course following AKI in an expedient manner. Here, we demonstrate the feasibility of using hyperpolarized carbon-13 MRI to image metabolic activity in the mice recovering from renal IRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.