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Abstract #2335

In vivo Assessment of Metabolic Derangements in Renal Ischemia-Reperfusion Injury using Carbon-13 HP-MRI

Mehrdad Pourfathi1,2, David D. Aufhauser3, Douglas R. Murken3, Zhonglin Wang3, Stephen J. Kadlecek1, Heather Gatens1, Ali Naji3, Matthew H. Levine3,4, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Surgery, Division of Transplant Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States, 4Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Renal ischemia repercussion injury (IRI) and its manifestation of acute kidney injury (AKI) is a significant source of morbidity in diverse medical and surgical scenarios, for which for which there is no current therapeutic modality. AKI contributes significantly to hospital stay, morbidity, and mortality. Despite the extensive metabolic derangements that accompany renal IRI, there is an absence of clinically useful markers to predict the clinical course following AKI in an expedient manner. Here, we demonstrate the feasibility of using hyperpolarized carbon-13 MRI to image metabolic activity in the mice recovering from renal IRI.

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