Abstract #2336

[13C]-tert-butanol-2-β-D-galactose: A potential new hyperpolarized imaging agent for in vivo imaging of senescent cells

Keshav Datta^1,2, Shie-Chau Liu¹, Stephen R Lynch³, Zixin Chen¹, Ralph Hurd⁴, Jianghong Rao¹, and Daniel Mark Spielman^1,2

¹Dept. of Radiology, Stanford University, Stanford, CA, United States, ²Dept. of Electrical Engineering, Stanford University, Stanford, CA, United States, ³Dept. of Chemistry, Stanford University, Stanford, CA, United States, ⁴Applied Sciences Lab, GE Healthcare, Menlo Park, CA, United States

We evaluated the potential for the use of ([13C]-tert-butanol-bGal as hyperpolarizeable agent for in vivo imaging of senescent cells. The chemical shift between [13C]-tert-butanol-bGal and bGal-cleaved [13C]-tert-butanol was found to be 7.4ppm, more than adequate for in vivo detection. [13C]-tert-butanol-bGal was also found to polarize well(~30%) with [13C]-tert-butanol-bGal and [13C]-tert-butanol yielding T1 relaxation times of 22s and 34s respectively, very promising for in vivo studies.

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