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Abstract #2344

Mis-Estimation and Bias of Hyperpolarized ADC Measurements Due to Slice Profile Effects

Jeremy W Gordon1, Eugene Milshteyn1, Irene Marco-Rius1, Michael Ohliger1, Daniel B Vigneron1, and Peder EZ Larson1

1Radiology & Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States

Hyperpolarized diffusion weighted imaging has the potential to noninvasively assess transporter expression and probe specific metabolite microenvironments. However, the imperfect RF excitation profile and the transient, non-recoverable hyperpolarization lead to non-uniform depletion of Mz. After multiple RF pulses, this results in excess signal at later excitations, potentially biasing ADC estimation. Scaling the slice-select gradient can correct for this deviation, minimizing bias and providing more precise ADC measurements of hyperpolarized substrates.

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