Abstract #2344

Mis-Estimation and Bias of Hyperpolarized ADC Measurements Due to Slice Profile Effects

Jeremy W Gordon¹, Eugene Milshteyn¹, Irene Marco-Rius¹, Michael Ohliger¹, Daniel B Vigneron¹, and Peder EZ Larson¹

¹Radiology & Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States

Hyperpolarized diffusion weighted imaging has the potential to noninvasively assess transporter expression and probe specific metabolite microenvironments. However, the imperfect RF excitation profile and the transient, non-recoverable hyperpolarization lead to non-uniform depletion of M_z. After multiple RF pulses, this results in excess signal at later excitations, potentially biasing ADC estimation. Scaling the slice-select gradient can correct for this deviation, minimizing bias and providing more precise ADC measurements of hyperpolarized substrates.

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