Jeremy W Gordon1, Eugene Milshteyn1, Irene Marco-Rius1, Michael Ohliger1, Daniel B Vigneron1, and Peder EZ Larson1
Hyperpolarized diffusion weighted imaging has the potential
to noninvasively assess transporter expression and probe specific metabolite
microenvironments. However, the imperfect RF excitation profile and the
transient, non-recoverable hyperpolarization lead to non-uniform depletion of Mz.
After multiple RF pulses, this results in excess signal at later excitations,
potentially biasing ADC estimation. Scaling the slice-select gradient can
correct for this deviation, minimizing bias and providing more precise ADC measurements
of hyperpolarized substrates.