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Abstract #2343

Optimization and application of bipolar gradient for flow-suppressed hyperpolarized 13C CSI in mouse liver at 9.4T

Hansol Lee1, Joonsung Lee2, Eunhae Joe1, Seungwook Yang1, Jae Eun Song1, Young-suk Choi3, Eunkyung Wang3, Ho-Taek Song3, and Dong-Hyun Kim1

1Department of Electrical & Electronic Engineering, Yonsei university, Seoul, Korea, Republic of, 2Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, Korea, Republic of, 3Department of Radiology, Yonsei University College of Medicine, Seoul, Korea, Republic of

In hyperpolarized 13C MRI, high signal intensity of vasculature can cause errors in quantification of metabolites or conversion rate constants. The bipolar gradient was used to suppress vascular signal for accurate quantification. However, the velocity of vessel can vary depending on anesthetic level and pulsation. Furthermore, additional T2* relaxation signal loss can be induced by delayed data acquisition in ultra-high field (9.4T) due to short T2*. In this study, the bipolar gradient was optimized to minimize additional signal loss and mitigate variable velocity, then the optimized bipolar gradient was implemented for hyperpolarized 13C CSI and applied to mouse liver experiment.

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