Abstract #2342

Dual-Echo EPI Sequence for Integrated Distortion Correction in 3D Time-Resolved Hyperpolarized 13C MRI

Benjamin J. Geraghty^1,2, Albert P. Chen³, and Charles H. Cunningham^1,2

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Dept. of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³GE Healthcare, Toronto, ON, Canada

A novel dual echo EPI sequence is proposed for providing a built-in correction for off-resonance in time resolved, volumetric hyperpolarized ¹³C metabolic mapping with [1-¹³C]pyruvate. The phase evolution between two echoes was used to correct EPI distortion and improve spatial registration with the underlying anatomy. A correction term obtained from a fully phase encoded dual echo EPI proton reference scan was required to account for odd/even echo asymmetry in the ¹³C phase maps. Proof-of-concept dual echo EPI in vivo rat data was acquired on a clinical 3T MR scanner and corrected images are presented.

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