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Abstract #2354

A comparison of lipid suppression by double inversion recovery, L1- and L2-regularisation for high resolution MRSI in the brain at 7 T

Gilbert Hangel1, Bernhard Strasser1, Michal Považan1, Martin Gajdošík1, Stephan Gruber1, Marek Chmelík1, Siegfried Trattnig1,2, and Wolfgang Bogner1

1MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Reliable lipid suppression is essential for robust quantification of parallel imaging accelerated high- resolution MRSI. This work compared the performance of non-selective lipid suppression using double inversion recovery (DIR) with the application of L1- and L2-regularisation during data processing for single-slice MRSI with a 64×64 matrix and a GRAPPA-acceleration of nine in five volunteers. While DIR featured the best lipid suppression, it increased the measurement time and reduced metabolite SNR. L1 and L2 did not have these downsides, but twice as much lipid signal remained, with L1 increasing the data pre-processing time before spectral quantification by a factor of six.

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