Abstract #2354

A comparison of lipid suppression by double inversion recovery, L1- and L2-regularisation for high resolution MRSI in the brain at 7 T

Gilbert Hangel¹, Bernhard Strasser¹, Michal Považan¹, Martin Gajdošík¹, Stephan Gruber¹, Marek Chmelík¹, Siegfried Trattnig^1,2, and Wolfgang Bogner¹

¹MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Reliable lipid suppression is essential for robust quantification of parallel imaging accelerated high- resolution MRSI. This work compared the performance of non-selective lipid suppression using double inversion recovery (DIR) with the application of L1- and L2-regularisation during data processing for single-slice MRSI with a 64×64 matrix and a GRAPPA-acceleration of nine in five volunteers. While DIR featured the best lipid suppression, it increased the measurement time and reduced metabolite SNR. L1 and L2 did not have these downsides, but twice as much lipid signal remained, with L1 increasing the data pre-processing time before spectral quantification by a factor of six.

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