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Abstract #2357

Measurement reproducibility of the spiral encoding GABA-edited MEGA-LASER 3D-MRSI in the brain at 3T

Petra Hnilicová1, Michal Považan2, Bernhard Strasser2, Ovidiu C Andronesi3, Dušan Dobrota1, Siegfried Trattnig2, and Wolfgang Bogner2

1Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, 2Department of Biomedical Imaging and Image-guided Therapy, MR Center of Excellence, Medical University of Vienna, Vienna, Austria, 3Department of Radiology, Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, United States

In vivo assessment of neurotransmitter levels can improve the understanding of several pathological processes. For non-invasive GABA+ and Glx mapping in vivo within one scan, we applied a spiral-encoded GABA-edited MEGA-LASER 3D-MRSI sequence with real time corrections, achieving the ~3 cc nominal resolution in ~20 minutes. Via test-retest assessment in 14 healthy volunteers (7 men/7 women) we confirmed the measurement reproducibility and inter- and intra-subject variability of GABA+ and Glx ratios and thus validated that our method may be used in (pre)clinical studies of neurotransmitters alterations in the brain at 3T.

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