Abstract #2360

Quantitative Comparison of SNR between High and Low Resolution of 3D Chemical Shift Imaging (CSI)

Byeong-Yeul Lee¹, Xiao-Hong Zhu¹, and Wei Chen¹

¹Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States

Spatial averaging of multiple high-resolution CSI (hrCSI) voxels is commonly employed to gain SNR and improve quantification of metabolites. Using in vivo 17-oxygen 3D CSI, we compared SNR between spatial averaging of multiple hrCSI voxels and a single voxel acquired with low-resolution CSI (lrCSI) with matched sample volume and position. SNR from voxel averaging was much lower than that of lrCSI caused mainly by the increased noise level by spectral summation. This study clearly demonstrates that the acquisition of high-resolution data with spatial averaging faces a large trade-off of SNR. Therefore, it should be taken consideration carefully for the choice of an appropriate voxel size of high-resolution CSI for in vivo study of neurological or metabolic diseases.

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