Abstract #2359

Fast and efficient free induction decay MRSI at 9.4 T: assessment of neuronal activation-related changes in the human brain biochemistry

Grzegorz L. Chadzynski^1,2, Jonas Bause², G. Shajan², Rolf Pohmann², Klaus Scheffler^1,2, and Philipp Ehses^1,2

¹Biomedical Magnetic Resonance, Eberhard-Karls University of Tübingen, Tübingen, Germany, ²High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany

The aim was to design a MRSI-FID sequence for ultra-high field applications with high acquisition speed and sampling efficiency. The sequence allows acquisition of a 32×32 voxel matrix within approximately 2 min, down to 30 sec using parallel imaging. We have examined the suitability of this approach for assessing biochemical changes in the human visual cortex during a visual stimulus. Obtained results were in accordance with other functional MRS studies and indicate that the developed sequence is suitable for rapid monitoring of stimulus evoked changes in human brain biochemistry at a very high spatial resolution.

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