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Abstract #2364

Ultrashort TE 3D spectroscopic imaging for high SNR imaging and bi-exponential signal decay characterization of sodium

Jetse S. van Gorp1, Paul W. de Bruin2, and Peter R. Seevinck1

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands

Sodium relaxation behavior has been related to structural and cellular integrity, which is of interest for early disease detection. However, the short T2* values, bi-exponential relaxation behavior and low sensitivity makes accurate signal characterization challenging. In this work a 3D-UTE-FID-SI sequence was developed to measure the sodium decay curve with a 32kHz temporal resolution and sub-ms TE to characterize the bi-exponential signal decay characteristics of sodium in vitro and in vivo.

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