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Abstract #2365

Accounting for GABA editing efficiency and macromolecule co-editing to allow inter-vendor comparisons of GABA+ measurements

Ashley D Harris1,2,3,4,5, Nicolaas AJ Puts1,5, Laura Rowland6, S. Andrea Wijtenburg6, Mark Mikkelsen7, Peter B Barker1,5, C. John Evans7, and Richard AE Edden1,5

1FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2CAIR Program, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada, 4Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, 5Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 6Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States, 7CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom

Differences in GABA+ MEGA PRESS acquisitions between vendors are quantified in terms of the editing efficiency of GABA and the fractional co-editing of macromolecules. Accounting for these two parameters results in moderate agreement among the different vendors considered.

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