Abstract #2366

Towards a neurochemical profile of the amygdala using SPECIAL at 3 tesla

Florian Schubert¹, Ralf Mekle¹, Simone Kühn², Jürgen Gallinat³, and Bernd Ittermann¹

¹Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, ²MPI for Human Development, Berlin, Germany, ³Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Since disturbed amygdala function is linked to psychiatric conditions insight into its biochemistry, particularly the neurotransmitters, is required. We combined the SPECIAL MRS sequence with FAST(EST)MAP implementation, corrections for frequency drift, relaxation, CSF volume, and a basis set including a measured macromolecule spectrum for quantification of metabolites in the amygdala in 20 volunteers at 3T. Beyond quantification of the three main metabolites plus myo-inositol with excellent precision, for the first time glutamate was determined reliably and separately from glutamine. Using a basis set without macromolecules introduced a systematic overestimation of concentrations. Glutamine and glutathione was quantifiable only in a subset of spectra.

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