Meeting Banner
Abstract #2366

Towards a neurochemical profile of the amygdala using SPECIAL at 3 tesla

Florian Schubert1, Ralf Mekle1, Simone Kühn2, Jürgen Gallinat3, and Bernd Ittermann1

1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2MPI for Human Development, Berlin, Germany, 3Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Since disturbed amygdala function is linked to psychiatric conditions insight into its biochemistry, particularly the neurotransmitters, is required. We combined the SPECIAL MRS sequence with FAST(EST)MAP implementation, corrections for frequency drift, relaxation, CSF volume, and a basis set including a measured macromolecule spectrum for quantification of metabolites in the amygdala in 20 volunteers at 3T. Beyond quantification of the three main metabolites plus myo-inositol with excellent precision, for the first time glutamate was determined reliably and separately from glutamine. Using a basis set without macromolecules introduced a systematic overestimation of concentrations. Glutamine and glutathione was quantifiable only in a subset of spectra.

This abstract and the presentation materials are available to members only; a login is required.

Join Here