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Abstract #2367

Estimation of  in vivo γ-aminobutyric acid (GABA) levels in the neonatal brain

Moyoko Tomiyasu1,2, Noriko Aida3, Jun Shibasaki4, Katsutoshi Murata5, Keith Heberlein6, Mark A. Brown7, Eiji Shimizu2, Hiroshi Tsuji1, and Takayuki Obata1

1National Institute of Radiological Sciences, Chiba, Japan, 2Chiba University, Chiba, Japan, 3Department of Radiology, Kanagawa Children's Medical Center, Yokohama, Japan, 4Kanagawa Children's Medical Center, Yokohama, Japan, 5Siemens, Tokyo, Japan, 6Biomedical Imaging Technology Center, Burlington, MA, United States, 7University of Colorado, Cary, NC, United States

We examined in vivo brain γ-aminobutyric acid (GABA) levels of neonates and compared them with those of children. In this study, 32 normal neonates and 12 normal children (controls) had their brain GABA levels measured using clinical 3T edited-MRS. The neonates exhibited significantly lower GABA+ levels than the children in both the basal ganglia and cerebellum, which is consistent with previous in vitro data. While significantly higher GABA+/Cr levels were detected in the neonatal cerebellum, care should be taken when comparing GABA+/Cr levels between different ages. This is the first report about the in vivo brain GABA levels of neonates.

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