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Abstract #2368

Assessment of Lipid Changes in Obese Calf Using Muti-Echo Echo-planar Correlated Spectroscopic Imaging

Rajakumar Nagarajan1, Raissa Souza1, Edward Xu1, Manoj K Sarma1, S. Sendhil Velan2, Cathy C Lee3, Theodore Hahn3, Catherine Carpenter4, Vay-Liang Go5, and M.Albert Thomas1

1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 3Geriatrics, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, 4UCLA Schools of Nursing, Medicine, and Public Health, Los Angeles, CA, United States, 5UCLA Department of Medicine, Los Angeles, CA, United States

Obesity is a serious public health problem associated with high rates of morbidity and mortality. One-dimensional MR spectroscopy suffers from overlapping spectral resonances which can complicate metabolite identification and quantitation. Two-dimensional spectroscopic techniques have been demonstrated in calf muscle to reduce the problem of spectral overlap. In this study, we used the four dimensional (4D) multi-echo echo planar correlated spectroscopic imaging (ME-EPCOSI) technique to quantify the lipids and metabolites in soleus, tibialis anterior and gastrocnemius calf muscles of obese and normal healthy subjects. The 4D ME-EPCOSI acquired data enabled less ambiguous quantitation of metabolites, unsaturated and saturated fatty acids in different calf muscle regions using IMCL ratios and unsaturation indices.

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