Abstract #2368

Assessment of Lipid Changes in Obese Calf Using Muti-Echo Echo-planar Correlated Spectroscopic Imaging

Rajakumar Nagarajan¹, Raissa Souza¹, Edward Xu¹, Manoj K Sarma¹, S. Sendhil Velan², Cathy C Lee³, Theodore Hahn³, Catherine Carpenter⁴, Vay-Liang Go⁵, and M.Albert Thomas¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, ³Geriatrics, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, ⁴UCLA Schools of Nursing, Medicine, and Public Health, Los Angeles, CA, United States, ⁵UCLA Department of Medicine, Los Angeles, CA, United States

Obesity is a serious public health problem associated with high rates of morbidity and mortality. One-dimensional MR spectroscopy suffers from overlapping spectral resonances which can complicate metabolite identification and quantitation. Two-dimensional spectroscopic techniques have been demonstrated in calf muscle to reduce the problem of spectral overlap. In this study, we used the four dimensional (4D) multi-echo echo planar correlated spectroscopic imaging (ME-EPCOSI) technique to quantify the lipids and metabolites in soleus, tibialis anterior and gastrocnemius calf muscles of obese and normal healthy subjects. The 4D ME-EPCOSI acquired data enabled less ambiguous quantitation of metabolites, unsaturated and saturated fatty acids in different calf muscle regions using IMCL ratios and unsaturation indices.

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