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Abstract #2373

Reproducibility and gender-related effects on macromolecule suppressed GABA and Glx metabolites

Muhammad Gulamabbas Saleh1, A Alhamud1, Jamie Near2, Frances Robertson1, André J.W. van der Kouwe3, and Ernesta M Meintjes1

1Human Biology, MRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, South Africa, 2Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

Several studies have characterized short and long term reproducibility of Glx and GABA+, but not macromolecule (MM) suppressed GABA. Further, gender-related differences have been observed in GABA+, but these may, in part, be due to inter-individual variations of MM. Motion and magnetic field inhomogeneity can hamper the consistent application of frequency-selective pulses at 1.7ppm necessary for effective GABA editing. We demonstrate that the shim and motion-navigated MEGA-SPECIAL sequence produces well-edited GABA and Glx spectra. LCModel quantification yields the best reproducibility. Observed gender-related differences in GABA highlight the need for gender-matching in studies investigating differences in GABA concentrations.

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