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Abstract #2378

Towards low power EPR Imaging using Frank poly-phase pulse sequence

Nallathamby Devasahayam1, Randall H. Pursley2, Thomas J. Pohida2, Shingo Matsumoto3, Keita Saito4, Sankaran Subramanian5, and Murali C. Krishna4

1Radiation Biology Branch, National Cancer Institute, Bethesda, MD, United States, 2Center for Information Technology, Bethesda, MD, United States, 3Graduate School of Information Science and Technology, Sapporo, Japan, 4National Cancer Institute, Bethesda, MD, United States, 5Indian Institute of Technology Madras, Chennai, India

Electron Paramagnetic Resonance (EPR) imaging is suited well for small animal physiological imaging with its unique capability of generating in vivo quantitative oxygen maps. The main bottleneck in scaling up pulsed EPR imaging to human anatomy is that the required RF power of US federal food and drug administration (FDA), specific absorption rate (SAR) limits. In Frank Sequence we are using power levels on the order of 250 microwatts in a crossed coil resonator with ~35 dB isolation. Using a 256 pulse polyphase Frank Sequence, it was possible to obtain images with good SNR.

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