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Abstract #2377

Tissue correction strategy impacts GABA quantification: a study in healthy aging

Ashley D Harris1,2,3,4, Eric Porges5, Adam J Woods5,6, Damon G Lamb5,7, Ronald A Cohen5, John B Williamson5,8, Nicolaas AJ Puts3,4, and Richard AE Edden3,4

1Radiology, University of Calgary, Calgary, AB, Canada, 2CAIR Program, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, 3Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 4FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, United States, 6Department of Neuroscience, University of Florida, Gainesville, FL, United States, 7Brain Rehabilitation and Research Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, United States, 8Brain Rehabilitation and Research Center, Brain Rehabilitation and Research Center, Gainesville, FL, United States

There are various strategies for tissue correction for MRS. Here, using data from a healthy aging cohort, we show that the selection of tissue correction method can change the conclusions that are drawn from data.

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