Abstract #2380

Enhancement of signal intensity using a wireless coil for FT-EPR oximetry study

Ayano Enomoto¹, Gadisetti V. R. Chandramouli², Alan P Koretsky³, Chunqi Qian⁴, Murali K Cherukuri¹, and Nallathamby Devasahayam¹

¹Radiation Biology Branch, National Cancer Institute, Bethesda, MD, United States, ²GenEpria Consulting Inc., Columbia, MD, United States, ³National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ⁴Department of Radiology, Michigan State university, East Lansing, MI, United States

Sensitivity enhancement is required to detect the weak signals with Fourier transform Electron Paramagnetic Resonance (FT-EPR). In the proposed method, a small amount of sample was placed at a distance less than half the diameter of the receiving surface coil. The signal was enhanced by a wirelessly pumped coil. Presently, we used the TCNQ for our studies to study signal enhancement. Here, we achieved 7-fold of improvement in signal intensity in compared with conventional FT-EPR acquisition. We will show the results of in vivo oximetry using oxygen sensing solids LiPc and LiNc in in vivo applications to measure tissue oxygenation.

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