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Abstract #2381

Assessment of serine quantification reproducibility using advanced 1H-MRS in the human brain at 3T

Homa Javadzadeh1,2 and Jean Théberge1,2,3

1Department of Medical Biophysics, University of Western Ontario, London, ON, Canada, 2Imaging Division, Lawson Health Research Institute, London, ON, Canada, 3Diagnostic Imaging Department, St. Joseph's Health Care, London, ON, Canada

D-serine supplements alleviate some of the most debilitating features of schizophrenia believed to be associated with glutamatergic abnormalities. Assessment of endogenous serine is impossible using standard proton Magnetic Resonance Spectroscopy (1H-MRS). This work employs a novel 1H-MRS sequence called DANTE-PRESS (D-PRESS) and presents test-retest reliability study for serine levels acquired at 3T in phantoms and initial data in two human subjects. We conclude that reproducibility and precision of serine measurements on a 3.0T scanner is sufficient to assess endogenous levels in vivo and is a valuable tool to examine abnormalities in schizophrenia and monitor supplementation.

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