Abstract #2381

Assessment of serine quantification reproducibility using advanced 1H-MRS in the human brain at 3T

Homa Javadzadeh^1,2 and Jean Théberge^1,2,3

¹Department of Medical Biophysics, University of Western Ontario, London, ON, Canada, ²Imaging Division, Lawson Health Research Institute, London, ON, Canada, ³Diagnostic Imaging Department, St. Joseph's Health Care, London, ON, Canada

D-serine supplements alleviate some of the most debilitating features of schizophrenia believed to be associated with glutamatergic abnormalities. Assessment of endogenous serine is impossible using standard proton Magnetic Resonance Spectroscopy (¹H-MRS). This work employs a novel¹H-MRS sequence called DANTE-PRESS (D-PRESS) and presents test-retest reliability study for serine levels acquired at 3T in phantoms and initial data in two human subjects. We conclude that reproducibility and precision of serine measurements on a 3.0T scanner is sufficient to assess endogenous levels in vivo and is a valuable tool to examine abnormalities in schizophrenia and monitor supplementation.

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