Abstract #2383

9.4 Tesla 1H-MRS of Glutamate and GABA in a 3.6 cubic-mm volume using an optimized UTE-STEAM sequence

Nicola Bertolino¹, Paul Polak¹, Marilena Preda^1,2, Robert Zivadinov^1,2, and Ferdinand Schweser^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology,Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ²MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

In-vivo 1H-MR spectroscopy is a non-invasive technique able to detect metabolites providing important information from investigated tissue. GABA and Glutamate are two metabolites altered in many neurological diseases, although challenging to quantify in vivo because of a number of technical issues: voxel localization, low concentration, short T2, overlapping peaks and spin-spin coupling. In this work we developed an optimized parameter set for an ultra-short TE STEAM.

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