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Abstract #2384

Effects of Storage Conditions on Transverse Relaxation in Bovine Articular Cartilage

Kyle W. Sexton1, Hasan Celik1, Kenneth W. Fishbein1, and Richard G. Spencer1

1National Institute on Aging, National Institutes of Health, Baltimore, MD, United States

Quantification of cartilage matrix components with nuclear magnetic resonance has potential applications to the early diagnosis of osteoarthritis. Ex-vivo cartilage samples are often used to observe the MR parameters of healthy and degraded cartilage. To ensure the accuracy of MR parameters, the storage of the explants is extremely important. DPBS is often used to immerse cartilage tissue specimens during imaging, with the assumption that it prevents dehydration. In this study it was found that storing BAC tissue explants in DPBS can rapidly and significantly increase the observed T2 values. An alternative storage medium to maintain T2 stability is Fluorinert.

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