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Abstract #2385

Frequency correction based on interleaved water acquisition improves spectral quality in MM-suppressed GABA measurements in vivo

Nicolaas AJ Puts1,2, Kimberly L Chan1, Ashley D Harris1,2,3,4, Peter B Barker1,2, and Richard AE Edden1,2

1Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 4Radiology, University of Calgary, Calgary, AB, Canada

MM-suppressed GABA measurements use symmetric editing of both MM and GABA signals. Frequency drift, either by gradient induced heating/cooling, or motion, significantly affects the editing efficiency of GABA and MM. To stabilize the center frequency, we interleaved the unsuppressed water acquisition throughout the scan and used it to correct the frequency, in eight healthy participants, and compared this to a condition without frequency correction. Frequency correction improves spectral quality of MM-suppressed GABA editing in vivo.

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