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Abstract #2386

Single volume localization without RF refocusing for dynamic hyperpolarized 13C MR spectroscopy

Albert P Chen1, Ralph E Hurd2, Angus Z Lau3, and Charles H Cunningham4,5

1GE Healthcare, Toronto, ON, Canada, 2GE Healthcare, Menlo Park, CA, United States, 3Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 4Physical Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Medical Biophysics, University of Toronto, Toronto, ON, Canada

A method for single volume dynamic hyperpolarized 13C MRS acquisition is proposed. Using a slice selective pulse-acquire pulse sequence with 2D spiral readout this technique enables 3D localization of the MRS data. By confining the readout trajectory to each dwell time, the raw data sampled during the trajectory are averaged by the digital filter, thus the output data represent only the center voxel and no k-space data sorting and reconstruction are required. This sequence can be used practically the same way as a standard pulse-acquire acquisition for HP13C experiments, but the spectrum will be localized to a 3D volume.

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