Abstract #2387

Metabolic ratios can increase or decrease sample size requirements and statistical significance in magnetic resonance spectroscopy

Sarah E. Hoch¹, Ivan I. Kirov², and Assaf Tal³

¹Radiology, Sheba Medical Center, Ramat-Gan, Israel, ²Radiology, New York University Langone Medical Center, New York, NY, United States, ³Chemical Physics, Weizmann Institute of Science, Rehovot, Israel

Metabolite ratios are often used to simplify metabolic quantification. It is often implicitly assumed that they are also statistically favorable when both numerator and denominator metabolites change in opposing manners. Herein, we show that even for such cases, both sample size requirements and statistical significance depend non-trivially on taking the ratio. We conclude that care must be taken when deciding between ratios and absolute quantification during study design.

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