Abstract #2389

Assessment of intracellular lipids of non-adipose pancreatic cells

Jan Weis¹, Lina Carlblom¹, Lars Johansson¹, Olle Korsgren², and Håkan Ahlström¹

¹Department of Radiology, Uppsala University, Uppsala, Sweden, ²Department of Immunology, Genetics and Pathology, Uppslala University, Uppsala, Sweden

A 1.5 T clinical scanner was used for proton MR spectroscopy (¹H-MRS) of human pancreas allografts. The main purpose was to estimate intracellular lipid content in non-adipose pancreatic cells. The secondary aim was to quantify total fat and choline-containing compounds. Spectrum processing was performed in the time domain using MRUI software package. It was demonstrated that ¹H-MRS is an effective method for non-invasive estimation of intracellular lipid content in non-adipose pancreatic cells. This knowledge could be helpful in studies of various aspects of β-cell function (insulin production).

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