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Abstract #2389

Assessment of intracellular lipids of non-adipose pancreatic cells

Jan Weis1, Lina Carlblom1, Lars Johansson1, Olle Korsgren2, and Håkan Ahlström1

1Department of Radiology, Uppsala University, Uppsala, Sweden, 2Department of Immunology, Genetics and Pathology, Uppslala University, Uppsala, Sweden

A 1.5 T clinical scanner was used for proton MR spectroscopy (1H-MRS) of human pancreas allografts. The main purpose was to estimate intracellular lipid content in non-adipose pancreatic cells. The secondary aim was to quantify total fat and choline-containing compounds. Spectrum processing was performed in the time domain using MRUI software package. It was demonstrated that 1H-MRS is an effective method for non-invasive estimation of intracellular lipid content in non-adipose pancreatic cells. This knowledge could be helpful in studies of various aspects of β-cell function (insulin production).

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