Abstract #2390

Assessment and retrospective correction of rotation-induced signal attenuation in diffusion-weighted spectroscopy

Michael Dacko¹, Benjamin Knowles¹, Patrick Hucker¹, Maxim Zaitsev¹, and Thomas Lange¹

¹Medical Physics, University Medical Center Freiburg, Freiburg, Germany

Diffusion-weighted spectroscopy of the brain is a highly motion-sensitive MR method as a consequence of the large voxel size and low metabolite diffusion coefficients. In this work, we correct for voxel displacement during DWS experiments with prospective motion correction and investigate the signal attenuation due to rotation-induced intra-voxel dephasing. Phantom experiments with 'synthetic' rotations confirmed the theoretically predicted signal attenuation. High correlation between rotational motion and attenuation of the residual water peak was observed in vivo. Retrospective rejection criteria based on the recorded motion tracking data and on the residual water peak amplitude are compared.

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