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Abstract #2391

Fast automatic voxel positioning with non-rigid registrations for improved between-subject consistency in MRS

Young Woo Park1, Dinesh K. Deelchand2, James M. Joers2, Brian J. Soher3, Peter B. Barker4, HyunWook Park1, Gülin Öz2, and Christophe Lenglet2

1School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN, United States, 3Department of Radiology, Duke University Medical Center, Durham, NC, United States, 4Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

During the typical acquisition of single-voxel Magnetic Resonance Spectroscopy (MRS) the corresponding voxel-of-interest (VOI) must be selected manually, which induces some degree of variability. To address this, several automated VOI positioning methods, using rigid registration and aimed at follow-up scans of the same subject, have been proposed. This approach can be generalized to cross-subject scans, but with additional considerations for the anatomical variability. We hypothesized that non-rigid registration methods will minimize inter-subject variability in the tissue content of the VOI. Here, we present an analysis of registration strategies aimed at a reliable cross-subject automatic VOI positioning for MRS data acquisition.

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