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Abstract #2392

MM-suppressed GABA measurements are highly susceptible to B0 field instability

Richard Anthony Edward Edden1,2, Ashley D. Harris1,2,3,4, Nicolaas Puts1,2, Kimberly L. Chan1,2,5, Michael Schar1, and Peter B. Barker1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology, University of Calgary, Calgary, AB, Canada, 4Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, 5Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, United States

J-difference-edited measurements of GABA are usually contaminated up to 50% by macromolecular (MM) signal. It is possible to suppress this signal using a symmetrical editing motif, which relies upon partially inverting the MM signals to an equal degree in the two halves of the edited experiment. In the event of B0 field offset, the symmetry breaks down and either positive or negative MM signal rapidly contaminates the measured GABA signal. Here, we investigate this issue using simulations and in vivo experiments.

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