Abstract #2392

MM-suppressed GABA measurements are highly susceptible to B0 field instability

Richard Anthony Edward Edden^1,2, Ashley D. Harris^1,2,3,4, Nicolaas Puts^1,2, Kimberly L. Chan^1,2,5, Michael Schar¹, and Peter B. Barker^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁴Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, ⁵Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, United States

J-difference-edited measurements of GABA are usually contaminated up to 50% by macromolecular (MM) signal. It is possible to suppress this signal using a symmetrical editing motif, which relies upon partially inverting the MM signals to an equal degree in the two halves of the edited experiment. In the event of B₀ field offset, the symmetry breaks down and either positive or negative MM signal rapidly contaminates the measured GABA signal. Here, we investigate this issue using simulations and in vivo experiments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.