Abstract #2393

HERMES: Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy

Kimberly L Chan^1,2,3, Nicolaas AJ Puts^2,3, Peter B Barker^2,3, and Richard AE Edden^2,3

¹Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy, HERMES, is a novel method of the simultaneous, separable detection of overlapping metabolite signals. Classic J-difference editing involves the acquisition of two subspectra, with editing pulses applied to the target molecule (ON) or not (OFF). HERMES edits multiple metabolites simultaneously by acquiring all combinations of OFF/ON for each (i.e. four experiments to edit two metabolites) and uses a Hadamard-like addition-subtraction reconstruction to generate separate edited spectra for each target metabolite. In this abstract, we describe the method and demonstrate its application to NAA/NAAG editing, using simulations, and phantom and in vivo experiments.

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