Abstract #2394

Resolving Choline from Taurine in In-Vivo Magnetic Resonance Spectra at 9.4 T

Marissa E. Fisher¹, Brennen J. Dobberthien¹, Anthony G. Tessier^1,2, and Atiyah Yahya^1,2

¹Department of Oncology, University of Alberta, Edmonton, AB, Canada, ²Department of Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada

The Cho peak at 3.2 ppm contains significant signal contamination from the taurine (Tau) resonance in rat and mouse brain spectra, even at the high field strength of 9.4 T. The purpose of this work it to optimise TE₁ and TE₂ (echo times) of a Point RESolved Spectroscopy (PRESS) sequence to minimize Tau signal in the Cho spectral region at 9.4 T by exploiting the J-coupling evolution of the Tau protons. The determined optimal {TE₁, TE₂} combination was found to be {25 ms, 50 ms}. The efficacy of the timings was verified on rat brain in vivo.

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