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Abstract #2395

Diffusion weighted MR spectroscopy without water suppression allows to use water as inherent reference signal to correct for motion-related signal drop

André Döring1, Victor Adalid Lopez1, Vaclav Brandejsky1, Roland Kreis1, and Chris Boesch1

1Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland

A non-water suppressed diffusion-weighting MR spectroscopy sequence based on metabolite-cycling and STEAM is presented and tested in-vitro and in-vivo. The water peak as an inherent reference facilitates a post processing correction of the signal drop induced in individual acquisitions by cardiac and other motion. The correction leads to improved spectral resolution on one hand, but more importantly also to more accurate fitting of ADC values that are found to be smaller than without correction and most likely closer to the true values - and hence better suited for physiological interpretation.

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