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Abstract #2396

Sustained GABA reduction induced by anodal Transcranial Direct Current Stimulation (tDCS) in motor cortex: A Proton Magnetic Resonance Spectroscopy Study

Harshal Jayeshkumar Patel1, Sandro Romanzetti2,3, Antonello Pellicano1, Kathrin Reetz2,3, and Ferdinand Binkofski1,4

1Division of Clinical Cognitive Sciences, Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany, 2Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany, 3Jülich Aachen Research Alliance (JARA) — Translational Brain Medicine, Aachen and Jülich, Germany, 4Research Center Jülich GmbH, Institute of Neuroscience and Medicine, Jülich, Germany

Transcranial direct current stimulation (tDCS) modulates cortical excitability. In this study we investigated long term effects of anodal stimulation on inhibitory neurotransmitter concentration using proton magnetic resonance spectroscopy (MRS). Our results indicates that excitatory tDCS cause locally reduction in GABA and it remains in decreased state over a period of 60 minutes presumably due to the decrease of activity of glutamic acid decarboxylase(GAD)67.

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